Tighter Glycemic Targets for GDM Not Tied to Lower Risk for LGA Infants
THURSDAY, Sept. 15, 2022 (HealthDay News) -- For women with gestational diabetes mellitus (GDM), use of tighter versus less tight glycemic targets does not reduce the risk for infants being born large for gestational age but does reduce serious infant morbidity, according to a study published online Sept. 8 in PLOS Medicine.
Caroline A. Crowther, M.B., Ch.B., M.D., from the University of Auckland in New Zealand, and colleagues conducted a stepped-wedge, randomized trial at 10 hospitals. All hospitals initially used less tight targets (fasting plasma glucose [FPG] <5.5 mmol/L). Every four months, two hospitals moved to tighter targets (FPG ≤5.0 mmol/L). Data were included for 598 women with 602 infants using tighter targets and 502 women with 506 infants using less tight targets.
The researchers found that the rate of large for gestational age was similar between the treatment target groups (14.7 versus 15.1 percent). When adjusting for gestational age at diagnosis of GDM, body mass index, ethnicity, and history of GDM, the composite serious health outcome for the infant of perinatal death, birth trauma, or shoulder dystocia was reduced in the tighter versus the less tight group (1.3 versus 2.6 percent). In the tighter group, there was an increase observed in the composite serious health outcome for women, including major hemorrhage, coagulopathy, embolism, and obstetric complications (5.9 versus 3.0 percent).
"These findings have direct relevance for clinical practice and can be used to aid decisions on the choice of treatment targets to use when discussing glycemic control with women with GDM," the authors write.
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Related Posts
Un gel podría ayudar a tratar el cáncer en los perros, y tal vez también en los niños
MARTES, 15 de noviembre de 2022 (HealthDay News) -- Un nuevo gel de...
Biden Administration May Back Second Booster Shots for All Adults
TUESDAY, July 12, 2022 (HealthDay News) -- The White House is weighing whether...
Turning 65 Brings Big Health Care Cost Savings, Study Finds
WEDNESDAY, Sept. 15, 2021 (HealthDay News) -- When Americans are eligible for...
Do Dentures Take a Toll on Good Nutrition?
TUESDAY, April 26, 2022 (HealthDay News) -- Dentures may take a bite out of your...