Study IDs Reference Levels for Serum Neurofilament Light Chain in Youth
TUESDAY, Aug. 8, 2023 (HealthDay News) -- Measures of serum neurofilament light chain (sNfL) clinically differentiate children with neurological conditions versus healthy children, according to a study published online July 28 in The Lancet Neurology.
Ahmed Abdelhak, M.D., from the University of California in San Francisco, and colleagues aimed to establish an age-adjusted sNfL reference range database in a population of 2,667 healthy children and adolescents (aged 0 to 22 years) and to validate the clinical applicability of this database in 220 pediatric patients (aged 1 to 19 years) with neurological conditions (epilepsy, traumatic brain injury, bacterial central nervous system infections, pediatric-onset multiple sclerosis, and myelin oligodendrocyte glycoprotein antibody-associated disease).
The researchers found that in the healthy population, sNfL concentrations decreased with age by an estimated 6.8 percent per year until age 10.3 years (estimated multiplicative effect per 1-year increase, 0.93; 95 percent confidence interval, 0.93 to 0.94; P < 0·0001) and was mostly stable thereafter up to age 22 years (1.00; 95 percent confidence interval, 0.52 to 1.94; P > 0.99). The magnitude of the effect of weight on sNfL concentrations was marginal and was independent of age. Among children with neurological conditions, age-adjusted sNfL z scores were higher versus healthy children and adolescents.
"Compared with absolute sNfL values, the use of sNfL z score was associated with higher effect size metrics and allowed for more accurate estimation of the extent of ongoing neuroaxonal damage in individual patients," the authors write.
Several authors disclosed ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Related Posts
Hospitals Struggling to Reach Time-Related Treatment Goals for STEMI
FRIDAY, Oct. 13, 2023 (HealthDay News) -- Challenges resulting from the COVID-19...
COVID Pandemic May Have Driven a Flu Strain Into Extinction
MONDAY, Oct. 25, 2021 (HealthDay News) -- It's well-known that COVID-19 pandemic...
Modified Atkins Diet Plus Drug Therapy Beneficial in Drug-Resistant Epilepsy
THURSDAY, Jan. 5, 2023 (HealthDay News) -- For adults and adolescents with...
Racial Disparities ID’d in Autosomal Dominant Polycystic Kidney Disease
TUESDAY, July 12, 2022 (HealthDay News) -- Black and Hispanic patients with...