GLP-1 RA Use May Up Risk for Gallbladder, Biliary Diseases
THURSDAY, March 31, 2022 (HealthDay News) -- Use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is associated with increased risks for gallbladder or biliary diseases, with a higher risk for GLP-1 RA use in weight loss, according to a review published online March 28 in JAMA Internal Medicine.
Liyun He, from the Peking Union Medical College Hospital in China, and colleagues conducted a systematic review of randomized controlled trials (RCTs) comparing the use of GLP-1 RA drugs with placebo or with non-GLP-1 RA drugs in adults to examine the association with gallbladder and biliary diseases. Data from 76 RCTs with 103,371 patients were included in the meta-analysis.
The researchers found that randomization to GLP-1 RA treatment among all included trials was associated with increased risks for gallbladder or biliary diseases (pooled relative risk [RR], 1.37), specifically cholelithiasis, cholecystitis, and biliary disease (RRs, 1.27, 1.36, and 1.55, respectively). GLP-1 RA use was associated with an elevated risk for gallbladder or biliary diseases in trials for weight loss (13 trials; RR, 2.29) and for type 2 diabetes and other diseases (63 trials; RR, 1.27). For all included trials, the risks for gallbladder or biliary diseases were higher with higher doses of GLP-1 RA use versus lower doses and for longer versus shorter duration of use.
"Physicians should be concerned about the increased risk of gallbladder or biliary disease associated with GLP-1 RA use, especially at the higher doses recommended for weight loss," the authors write.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Related Posts
Aumentan unos defectos congénitos del pene. ¿Las toxinas ambientales tienen la culpa?
VIERNES, 20 de enero de 2023 (HealthDay News) -- Los médicos están observando un...
AHA News: Doctors Said Weight and Stress Caused Her Symptoms. They Came From a Blocked Heart Artery.
WEDNESDAY, April 26, 2023 (American Heart Association News) -- After a week of...
Could Your Genes Be to Blame for Your Kid’s Aversion to Broccoli?
THURSDAY, Sept. 23, 2021 (HealthDay News) -- Parents and their children often...
Asymptomatic SARS-CoV-2 Infection Seems to Be Less Common
MONDAY, Feb. 28, 2022 (HealthDay News) -- Completely asymptomatic severe acute...