Frailty Common in RA, Linked to Mortality, Hospitalization
MONDAY, March 21, 2022 (HealthDay News) -- Frailty is common in rheumatoid arthritis (RA) and is associated with hospitalization and mortality, according to a study published online March 16 in RMD Open.
Peter Hanlon, M.B.Ch.B., from the University of Glasgow Institute of Health and Wellbeing in the United Kingdom, and colleagues examined the prevalence of frailty in RA and its association with disease activity, all-cause mortality, and hospitalization among patients identified from the Scottish Early Rheumatoid Arthritis (SERA) inception cohort and the U.K. Biobank. Frailty was quantified using the frailty index in both datasets and with the frailty phenotype in the U.K. Biobank.
The researchers found that frailty was common in SERA (12 percent moderate; 0.2 percent severe) and in the U.K. Biobank (20 percent moderate; 3 percent severe) based on the frailty index. Using the frailty phenotype, 23 percent in the U.K. Biobank were frail. In SERA, the frailty index was associated with the Disease Activity Score in 28 joints (DAS28); in both cohorts, the frailty index was associated with age and female sex. In SERA, mean frailty decreased as DAS28 lessened over time with treatment. There was an association noted for the frailty index with all-cause mortality (hazard ratios for moderate/severe frailty versus robust, 4.14 and 1.68 in SERA and the U.K. Biobank, respectively) and with unscheduled hospitalization (incidence rate ratios, 2.27 and 2.74 in SERA and the U.K. Biobank, respectively). Frailty phenotype was associated with mortality and hospitalization in the U.K. Biobank.
"Our findings certainly indicate that some people with frailty and active rheumatoid arthritis have the potential to improve their frailty status with treatment of their RA," Hanlon said in a statement.
Related Posts
Emergency Department Capacity Not Keeping Up With Demand in California
WEDNESDAY, June 28, 2023 (HealthDay News) -- Emergency department capacity in...
Drug Overdoses Are Killing Men at Much Higher Rates Than Women
THURSDAY, June 15, 2023 (HealthDay News) -- American men die of drug overdoses...
Infant Head-Shaping Pillows Are Useless and Dangerous to Baby, FDA Warns
FRIDAY, Nov. 4, 2022 (HealthDay News) – Infant head-shaping pillows are not...
Merck pedirá a la FDA la aprobación de emergencia de su nueva pastilla antiviral contra la COVID
VIERNES, 1 de octubre de 2021 (HealthDay News) -- La gigante farmacéutica Merck...