BP Genetic Risk Score Linked to Risk for CV Events in Type 2 Diabetes
MONDAY, April 4, 2022 (HealthDay News) -- For individuals with type 2 diabetes, increases in a polygenic risk score (PRS) for elevated blood pressure (BP) are associated with an increased risk for adverse cardiovascular events, according to a research letter published online April 4 in Hypertension.
Vibhu Parcha, M.B.B.S., from the University of Alabama at Birmingham, and colleagues conducted a post hoc analysis of multiethnic Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial participants to examine the association of BP PRS with BP traits and cardiovascular outcomes among individuals with type 2 diabetes. Genetic data were available for 6,335 of 10,251 ACCORD participants.
The researchers found that in the multivariable adjusted model, higher systolic and diastolic BP were seen per standard deviation (SD) increase in BP PRS (β, 1.93 and 0.65, respectively). The risk for adverse cardiovascular events was increased 12 percent per SD increase in the BP PRS (hazard ratio, 1.12). No interaction was seen between glycemic control therapy and BP PRS in terms of the primary outcome (composite of nonfatal myocardial infarction, stroke, or cardiovascular death).
"A genetic risk score may be helpful for people newly diagnosed with type 2 diabetes to identify who should have more intense lifestyle changes, such as changes in diet and exercise, and more aggressive management of weight, blood pressure and smoking cessation," a coauthor said in a statement.
The ACCORD study was funded by pharmaceutical and health care companies.
Abstract/Full Text (subscription or payment may be required)
Related Posts
In Tibetan Monk Study, Hints That Meditating Can Alter Gut Microbes
TUESDAY, Jan. 17, 2023 (HealthDay News) -- Meditation might help a person’s gut...
Positive Five-Year Outcomes Seen for Nivolumab in Resectable Lung Cancer
WEDNESDAY, Feb. 15, 2023 (HealthDay News) -- For patients with resectable...
U.S. Health Officials Faced Widespread Harassment During Pandemic
MONDAY, March 21, 2022 (HealthDay News) -- Harassment of U.S. public health...
Reduction in Vial Size of Aducanumab Could Yield Savings
MONDAY, June 27, 2022 (HealthDay News) -- A reduction in vial size of aducanumab...