Vaccine Effectiveness Against SARS-CoV-2 Infection Wanes Over Time
TUESDAY, June 14, 2022 (HealthDay News) -- Vaccine effectiveness (VE) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and symptomatic COVID-19 wanes over time, but remains strong against severe COVID-19, according to a review published online May 7 in BMC Infectious Diseases.
Paddy Ssentongo, M.D., Ph.D., from the Penn State College of Medicine and Milton S. Hershey Medical Center, and colleagues conducted a systematic review and meta-analysis of the duration of VE against SARS-CoV-2 infection, symptomatic COVID-19, and severe COVID-19. Data were included from 18 studies representing nearly 7 million individuals.
The researchers found that VE against all SARS-CoV-2 infections decreased from 83 percent in the first month after completion of the original vaccination series to 22 percent at five months or longer. In addition, a decline was seen in VE against symptomatic COVID-19, from 94 percent in the first month after vaccination to 64 percent by the fourth month. For all ages, VE against severe COVID-19 was high overall, with VE of 90 percent at five months or longer after full vaccination. In individuals aged ≥65 years and those who received Ad26.COV2.S, VE against severe COVID-19 was lower.
"COVID-19 vaccines are critical for ending the pandemic, and even if their effectiveness against infection wanes, they provide key and important protection against severe COVID-19 disease that can lead to hospitalization," Ssentongo said in a statement. "Future studies will need to explore the evolution of effectiveness against omicron and newer variant-related hospitalizations."
Related Posts
Stress-Management Interventions May Aid Health Care Workers
WEDNESDAY, May 31, 2023 (HealthDay News) -- Stress-management interventions may...
Sequencing IDs Genetic Diagnoses for Sensorineural Hearing Loss
TUESDAY, Jan. 17, 2023 (HealthDay News) -- For children with bilateral...
Un estudio muestra un potente nuevo objetivo para salvar vidas de la EPOC
LUNES, 22 de mayo de 2023 (HealthDay News) -- Unos investigadores quizá hayan...
Inflammation Linked to Inferior Outcomes in Leukemia
WEDNESDAY, Jan. 18, 2023 (HealthDay News) -- A unique inflammation signature, in...