Extent of Tumor Resection Linked to Overall Survival in Low-Grade Glioma
TUESDAY, Jan. 17, 2023 (HealthDay News) -- For patients with diffuse low-grade glioma, the extent of surgical tumor resection (EOR) is associated with overall survival (OS), with improved OS seen with EOR ≥75 percent, according to a study published online Jan. 4 in the Journal of Clinical Oncology.
Shawn L. Hervey-Jumper, M.D., from the University of California in San Francisco, and colleagues conducted a 20-year retrospective cohort study involving 392 patients with Isocitrate dehydrogenase-mutant grade 2 glioma to examine the combined effects of volumetric EOR and molecular and clinical factors on OS and progression-free survival. The OS results were validated in two external cohorts with 365 participants.
The researchers identified three survival risk groups using a recursive partitioning analysis. The shortest median OS was seen in two subsets of patients with astrocytoma: those with postoperative tumor volume (TV) >4.6 mL and those with preoperative TV >43.1 mL and postoperative TV of ≤4.6 mL. Patients with astrocytoma who had chemotherapy with preoperative TV ≤43.1 mL and postoperative TV ≤4.6 mL and patients with oligodendroglioma with preoperative TV >43.1 mL and residual TV ≤4.6 mL or postoperative residual volume >4.6 mL had intermediate OS. Astrocytoma patients with preoperative TV ≤43.1 mL and postoperative TV ≤4.6 mL who received no chemotherapy and oligodendroglioma patients with preoperative TV ≤43.1 mL and postoperative TV ≤4.6 mL had the longest OS. Survival outcomes were improved with EOR ≥75 percent.
"Even for oligodendrogliomas, there is no question that maximal resection is critical for enhancing survival," Hervey-Jumper said in a statement.
Several authors disclosed financial ties to the biopharmaceutical, medical device, and health care industries.
Abstract/Full Text (subscription or payment may be required)
Related Posts
Una intervención en la infancia podría ayudar a prevenir algunos casos de autismo, según un estudio
MIÉRCOLES, 21 de septiembre de 2021 (HealthDay News) -- Los bebés pueden mostrar...
COVID Rapid Test Makers Struggling to Meet Demand
FRIDAY, Jan. 21, 2022 (HealthDay News) -- Shortages of both supplies and workers...
Post-COVID Risk for Blood Clot Lasts at Least 6 Months
THURSDAY, April 7, 2022 (HealthDay News) -- COVID-19 increases people's risk of...
Los expertos en salud respaldan que se abandonen las máscaras y las pruebas para los viajes por avión
VIERNES, 25 de marzo de 2022 (HealthDay News) -- Las compañías aéreas de EE. UU....