Cesarean Birth May Be Associated With Increased Childhood Cancer Risk
TUESDAY, March 22, 2022 (HealthDay News) — Cesarean birth seems to be associated with increased risk of cancer during childhood, especially lymphoma and sarcoma, according to a study published online March 17 in Acta Paediatrica.Sophie Marcoux, M.D.,…
Learn MoreIncidence of Metastatic Prostate Cancer Up From 2010 to 2018
TUESDAY, March 22, 2022 (HealthDay News) — The incidence rates of metastatic prostate cancer (mPCa) have increased significantly and coincide with the U.S. Preventive Services Task Force (USPSTF) recommendations against prostate cancer screening, according to a study published online March 14 in JAMA Network Open.
Mihir M. Desai, M.D., from University of Southern California in Los Angeles, and colleagues used the Surveillance, Epidemiology, and End Results database (SEER; 2004 through 2018) to identify 836,282 patients with prostate cancer. Incidence trends of mPCa were examined for before and after USPSTF recommendations against routine prostate cancer screening.
The researchers found that among men aged 45 to 74 years, the incidence rate of distant mPCa (SEER Summary staging) remained stable from 2004 to 2010 (annual percentage change [APC], −0.4 percent; 95 percent confidence interval [CI], −1.7 to 1.1 percent; P = 0.60), but increased significantly from 2010 to 2018 (APC, 5.3 percent; 95 percent CI, 4.5 to 6.0 percent; P
“This study suggests that the incidence of mPCA is increasing and might be temporally associated with changes in clinical policy and/or practice (e.g., USPSTF guidelines), which may explain such rapid changes in cancer epidemiological trends,” the authors write.
Two authors disclosed financial ties to the medical technology industry.
Learn MoreLow SARS-CoV-2 Positivity for Babies Born to Moms With COVID-19
TUESDAY, March 22, 2022 (HealthDay News) — Babies born to mothers with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have low rates of SARS-CoV-2 positivity, according to a review published online March 16 in The BMJ.John All…
Learn MoreDeficits in Cancer Screening at Most Facilities During Pandemic
TUESDAY, March 22, 2022 (HealthDay News) — Most accredited cancer programs in the United States reported a decline in cancer screening during the pandemic, most notably in colorectal cancer, according to a study published online March 21 in Cancer.Ra…
Learn MoreChallenges Persist for Pediatric Clinical Trials
TUESDAY, March 22, 2022 (HealthDay News) — Early discontinuation and nonreporting/nonpublication of findings continue to be common issues for conducting pediatric clinical trials, according to a study published online March 22 in Pediatrics.
Ryan Brewster, M.D., from the Stanford University School of Medicine in California, and colleagues characterized the prevalence of and factors associated with early discontinuation, results reporting, and publication of clinical trials enrolling participants
The researchers found that 11.1 percent of the trials were stopped early; the predominant reason for discontinuation was recruitment failure. Results were reported for 23.5 percent of completed trials; 38.8 percent were published within three years of completion. Over the study period, there was a significant improvement observed in rates of discontinuation and publication. The odds of discontinuation were lower for government-sponsored trials and academic trials versus industry trials (adjusted odds ratios, 0.72 and 0.64, respectively), and they were more likely to be published (adjusted odds ratios, 1.94 and 1.61, respectively). The likelihood of reporting results was lowest for academic trial investigators (adjusted odds ratio, 0.34).
“As the pediatric clinical trial ecosystem expands, so too must the mechanisms to address unique ethical, economic, and epidemiological barriers be prioritized,” the authors write. “Ultimately, addressing ongoing gaps in pediatric trial completion and availability of research findings will ensure that all children receive the highest quality, evidence-based care.”
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Learn MoreReview Explores Telehealth for Substance Use Disorders
TUESDAY, March 22, 2022 (HealthDay News) — The use of telehealth for the treatment of substance use disorders (SUDs) is addressed in a review and clinical practice guideline published online March 22 in the Annals of Internal Medicine.Stacey Uhl, fro…
Learn MoreMeds, Exercise Recommended for Stroke Prevention After sICAS
TUESDAY, March 22, 2022 (HealthDay News) — For patients with symptomatic intracranial atherosclerotic arterial stenosis (sICAS), initial treatment should comprise medications and exercise, and not percutaneous transluminal angioplasty and stenting, according to a practice advisory published online March 21 in Neurology.
Tanya N. Turan, M.D., from the Medical University of South Carolina in Charleston, and colleagues reviewed treatments for reducing the risk of recurrent stroke or death in patients with sICAS and developed recommendations for management. The resulting practice advisory has been endorsed by the American Heart Association/American Stroke Association, Neurocritical Care Society, and Society of Vascular and Interventional Neurology.
The authors note that clinicians should recommend 325 mg/d aspirin for long-term prevention of stroke and death; to further reduce stroke risk in patients with severe (70 to 99 percent) sICAS who have low risk of hemorrhagic transformation, addition of 75 mg/day clopidogrel to aspirin for up to 90 days is recommended. For patients with sICAS, clinicians should recommend high-intensity statin therapy to achieve a goal low-density lipoprotein cholesterol level
“Reviewing all of the evidence that has accumulated over the last two decades, we found that the research shows that medical management is more beneficial for people as an initial treatment,” Turan said in a statement.
Several authors disclosed financial ties to the pharmaceutical and medical device industries.
Learn MoreExercise Intervention Evaluated in Young Cancer Patients
TUESDAY, March 22, 2022 (HealthDay News) — The Yo-Yo AD, an intermittent recovery test, can be used to assess the impact of a precision-based exercise intervention among children, adolescents, and young adults with hematologic malignancies, according…
Learn MoreEffectiveness of Ad26.COV2.S Vaccine Stable for Six Months
TUESDAY, March 22, 2022 (HealthDay News) — The vaccine effectiveness (VE) of Ad26.COV2.S was stable over six months, including during a period of delta variant predominance, according to a study published online March 17 in JAMA Network Open.Jennifer…
Learn MoreNo Myocarditis Recurrence After SARS-CoV-2 Vaccination
TUESDAY, March 22, 2022 (HealthDay News) — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination seems safe for patients with prior history of myocarditis, with no evidence of recurrence, according to a study presented at ESC Acute…
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