Tumor-Infiltrating Lymphocytes Up PFS in Advanced Melanoma
THURSDAY, Dec. 8, 2022 (HealthDay News) -- For patients with advanced melanoma, infusion of tumor-infiltrating lymphocytes (TIL) is associated with significantly longer progression-free survival than ipilimumab treatment, according to a study published in the Dec. 8 issue of the New England Journal of Medicine.
Maartje W. Rohaan, M.D., from Amsterdam University Medical Center, and colleagues conducted a phase 3, multicenter, open-label trial involving 168 patients with unresectable stage IIIC or IV melanoma who were randomly assigned to receive either TIL or anti-cytotoxic T-lymphocyte antigen 4 therapy (ipilimumab; 84 patients in each group). Nonmyeloablative, lymphodepleting chemotherapy was given prior to infusion of TILs, which was followed by high-dose interleukin-2.
The researchers found that in the intention-to-treat population, the median progression-free survival was 7.2 and 3.1 months in the TIL and ipilimumab groups, respectively (hazard ratio for progression or death, 0.50). An objective response occurred in 49 and 21 percent of the patients, respectively. Median overall survival was 25.8 and 18.9 months in the TIL and ipilimumab groups, respectively. All patients who received TILs and 57 percent of those who received ipilimumab had treatment-related adverse events of grade 3 or higher; these events were mainly chemotherapy-related myelosuppression in the TIL group.
"TILs can be successfully generated from resected melanoma metastases in patients with advanced melanoma," the authors write. "Treatment with TILs was associated with significantly longer progression-free survival than treatment with ipilimumab."
Several authors disclosed financial ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Related Posts
Entre las mujeres de las minorías, una vitamina D baja podría aumentar el riesgo de cáncer de mama
LUNES, 25 de abril de 2022 (HealthDay News) -- Una vitamina D insuficiente...
¿Cómo afectó la pandemia a la presión arterial de los estadounidenses?
JUEVES, 3 de noviembre de 2022 (HealthDay News) -- Aunque los niveles de presión...
Bacteria at Day Care Might Raise Kids’ Odds for Asthma
TUESDAY, Sept. 12, 2023 (HealthDay News) -- Certain combinations of bacteria...