Telmisartan Linked to Reduced Risk for Alzheimer Disease in Black Patients
MONDAY, Nov. 7, 2022 (HealthDay News) -- In African American patients, telmisartan is associated with a reduced risk for Alzheimer disease (AD), according to a study published online Nov. 4 in Alzheimer's & Dementia.
Pengyue Zhang, Ph.D., from Indiana University in Indianapolis, and colleagues examined the association between telmisartan exposure and AD outcomes in race-conscious pharmacoepidemiologic studies of 5.62 million older individuals aged 60 years and older. A Mendelian randomization (MR) analysis of large ethnically diverse genetic data was performed to test likely causal relationships.
The researchers found a significant association of moderate/high versus low/no telmisartan exposure with a reduced incidence of AD in African Americans, but not in non-Hispanic European Americans. In African Americans, sensitivity and sex-/age-stratified patient subgroup analyses showed that telmisartan's medication possession ratio and average hypertension daily dosage were significantly associated with a stronger reduction in the incidence of AD and dementia. Using MR analysis, African American-specific beneficial effects of telmisartan were identified for AD.
"Considering race-specific drug responses holds potential for drastically improving patient care," a coauthor said in a statement. "Identifying these candidate drugs can also reveal more information about the disease itself through referencing the medicine's targets."
Several authors disclosed financial ties to the biopharmaceutical industry.
Related Posts
Target Recalls Over 200,000 Weighted Blankets After 2 Children Suffocated
TUESDAY, Dec. 27, 2022 (HealthDay News) – The U.S. Consumer Product Safety...
Risk for Cardiovascular Disease Increased for Patients With Celiac Disease
TUESDAY, Jan. 31, 2023 (HealthDay News) -- Patients with celiac disease have an...
Un estudio encuentra buenos resultados a largo plazo en la apendicitis tratada sin cirugía
JUEVES, 10 de agosto de 2023 (HealthDay News) -- A la mayoría de las personas...
Risk for Contralateral Breast Cancer Higher for Certain Pathogenic Variant Carriers
FRIDAY, Feb. 3, 2023 (HealthDay News) -- Women diagnosed with breast cancer who...