Use of Nonselective β-Blockers Tied to Lower Risk for Total Knee Arthroplasty

FRIDAY, Sept. 15, 2023 (HealthDay News) -- The use of nonselective β-blockers is associated with a lower likelihood of undergoing total knee arthroplasty (TKA), according to a study published online Sept. 5 in the Journal of Bone & Joint Surgery.
Iskandar Tamimi, M.D., Ph.D., from University of Málaga in Spain, and colleagues assessed the likelihood of TKA among patients with osteoarthritis (OA) who were being treated with β-blockers. The analysis included 300 patients who underwent TKA and 300 patients who did not undergo TKA.
The researchers found that compared with nonusers, any use of β-blockers during the follow-up period was associated with a reduction in the likelihood of undergoing TKA (adjusted odds ratio [aOR], 0.51; 95 percent confidence interval [CI], 0.34 to 0.77), with differences observed between use of selective β1-blockers (aOR, 0.69; 95 percent CI, 0.36 to 1.31) and nonselective β1-blockers (aOR, 0.42; 95 percent CI, 0.24 to 0.70). Risk varied by proportion of days covered (PDC): PDC of <0.25: aOR, 0.62 (95 percent CI, 0.21 to 1.85); PDC of ≥0.25 to <0.75: aOR, 0.32 (95 percent CI, 0.09 to 1.22); and PDC of ≥0.75: aOR, 0.55 (95 percent CI, 0.34 to 0.88). Risk also varied by cumulative effect of β-blockers: less than one year: aOR, 0.41 (95 percent CI, 0.20 to 0.85); ≥1 to <5 years: aOR, 0.52 (95 percent CI, 0.21 to 1.33); and ≥5 years: aOR, 0.36 (95 percent CI, 0.22 to 0.60).
"We believe that the role of β-blockers in the management of OA could go beyond an analgesic treatment and that these drugs potentially could interfere with the degenerative processes in the cartilage," the authors write.
Related Posts
Risk for Pregnancy Loss Increased With Employment During Pregnancy
WEDNESDAY, Jan. 25, 2023 (HealthDay News) -- The risk for pregnancy loss is...
¿Vista cansada en el trabajo? Obtenga alivio con la regla 20-20-20
MARTES, 27 de septiembre de 2022 (HealthDay News) -- Mirar fijamente la pantalla...
Las garrapatas: este verano, conozca sus riesgos
MARTES, 20 de junio de 2023 (HealthDay News) -- Las garrapatas pueden ser un...
Alcohol-Related Cirrhosis Tied to Lower Survival Post-ICU
TUESDAY, Feb. 8, 2022 (HealthDay News) -- Critically ill patients with...