In-Hospital Mortality Evaluated for SARS-CoV-2-Linked Sepsis
WEDNESDAY, Oct. 4, 2023 (HealthDay News) — From March 2020 to November 2022, there was a decline in crude in-hospital mortality for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated sepsis, according to a study published online …
Learn MoreGemcitabine, Cisplatin, Nivolumab Facilitate Bladder Sparing
WEDNESDAY, Oct. 4, 2023 (HealthDay News) — For patients with muscle-invasive bladder cancer (MIBC), treatment with gemcitabine, cisplatin, plus nivolumab facilitates bladder sparing, according to a study published online Oct. 2 in Nature Medicine.
Matthew D. Galsky, M.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues conducted a phase 2 study of 76 patients with MIBC who received four cycles of gemcitabine, cisplatin, plus nivolumab followed by clinical restaging. Patients who achieved a clinical complete response (cCR) could proceed without cystectomy.
Of the patients, 33 achieved a cCR (43 percent); 32 of the 33 opted to forgo immediate cystectomy. The researchers found that the positive predictive value of cCR for a composite outcome of two-year metastasis-free survival in patients forgoing immediate cystectomy or ATM, RB1, FANCC, and ERCC2) or increased tumor mutational burden. There was an association noted between the baseline and on-treatment immune contexture with clinical outcomes.
“Treatment for muscle-invasive bladder cancer is in need of major improvements from both a quality-of-life and an effectiveness standpoint,” Galsky said in a statement. “If additional research confirms our findings, this may lead to a new paradigm in the treatment of muscle-invasive bladder cancer.”
Several authors disclosed ties to the biopharmaceutical and medical technology industries.
Learn MoreShorter Course of Radiation May Be Safe for Women Undergoing Breast Reconstruction
WEDNESDAY, Oct. 4, 2023 (HealthDay News) — Breast cancer patients who undergo a mastectomy can probably benefit from a shorter course of more intense radiation therapy, a new study indicates.Hypofractionated radiation therapy — which provides a highe…
Learn MoreLargest-Ever Study of Suicide Genetics Gives Clues to Who’s at Risk
WEDNESDAY, Oct. 4, 2023 (HealthDay News) — New research has discovered 12 gene variants that may be tied to an increased risk of attempting suicide. These genes also may have links with physical and mental health woes, including chronic pain, attenti…
Learn MoreMachine Learning Can Better ID Who Needs Lung Cancer Screening
TUESDAY, Oct. 3, 2023 (HealthDay News) — A machine learning model that uses only data on age, smoking duration, and pack-years can predict lung cancer risk and identify who needs lung cancer screening with better performance than currently used metho…
Learn MoreMajor Drug Companies Agree to Price Negotiations With U.S. Government
TUESDAY, Oct. 3, 2023 (HealthDay News) — Pharmaceutical companies that make the 10 prescription drugs chosen to be the first for price negotiations for Medicare patients have agreed to talks with the government.The Biden administration announced Tues…
Learn MoreMore Than 75,000 Kaiser Permanente Union Workers Could Strike on Wednesday
TUESDAY, Oct. 3, 2023 (HealthDay News) — Health care workers who serve millions of Americans could strike Wednesday if Kaiser Permanente and union workers do not reach an agreement.More than 75,000 members of the Coalition of Kaiser Permanente Unions…
Learn MoreLa lactancia materna en la infancia se relaciona con un peso más saludable en el futuro de los niños
MARTES, 3 de octubre de 2023 (HealthDay News) — La ciencia revela que lo que un bebé come, o cómo lo come, puede tener un impacto en su peso y salud futura.Un nuevo estudio respalda esa afirmación. Encontró que los niños de 9 años que habían sido amam…
Learn MoreA los microbios les encantan los ‘puntos calientes’ en tu cuerpo
MARTES, 3 de octubre de 2023 (HealthDay News) — La abuela lo sabía desde siempre: ciertos lugares en el cuerpo son “puntos calientes” para microbios poco saludables.Esa noción, a la que los autores de un nuevo estudio llamaron “la hipótesis de la abue…
Learn MoreMajor Drug Companies Agree to Price Negotiations With U.S. Government
TUESDAY, Oct. 3, 2023 (HealthDay News) — Pharmaceutical companies that make the 10 prescription drugs chosen to be the first for price negotiations for Medicare patients have agreed to talks with the government.The Biden administration announced Tues…
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