Selenium Not Linked to Recurrence of Non-Muscle-Invasive Bladder Cancer
WEDNESDAY, Oct. 18, 2023 (HealthDay News) — For patients with non-muscle-invasive bladder cancer (NMIBC), selenium supplementation does not reduce the risk for recurrence, while vitamin E is associated with an increased risk for recurrence, according…
Learn MoreTreatment Strategy Helps People With Advanced Bladder Cancer Retain the Organ
TUESDAY, Oct. 10, 2023 (HealthDay News) — “Listen, I’m not a Pollyanna,” New Yorker David Cabelis makes clear. “I’m a cab driver.”“But I was diagnosed with this cancer,” the 72-year old said. “Bladder cancer, that’s what I had, and then I had this tr…
Learn MoreGemcitabine, Cisplatin, Nivolumab Facilitate Bladder Sparing
WEDNESDAY, Oct. 4, 2023 (HealthDay News) — For patients with muscle-invasive bladder cancer (MIBC), treatment with gemcitabine, cisplatin, plus nivolumab facilitates bladder sparing, according to a study published online Oct. 2 in Nature Medicine.
Matthew D. Galsky, M.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues conducted a phase 2 study of 76 patients with MIBC who received four cycles of gemcitabine, cisplatin, plus nivolumab followed by clinical restaging. Patients who achieved a clinical complete response (cCR) could proceed without cystectomy.
Of the patients, 33 achieved a cCR (43 percent); 32 of the 33 opted to forgo immediate cystectomy. The researchers found that the positive predictive value of cCR for a composite outcome of two-year metastasis-free survival in patients forgoing immediate cystectomy or ATM, RB1, FANCC, and ERCC2) or increased tumor mutational burden. There was an association noted between the baseline and on-treatment immune contexture with clinical outcomes.
“Treatment for muscle-invasive bladder cancer is in need of major improvements from both a quality-of-life and an effectiveness standpoint,” Galsky said in a statement. “If additional research confirms our findings, this may lead to a new paradigm in the treatment of muscle-invasive bladder cancer.”
Several authors disclosed ties to the biopharmaceutical and medical technology industries.
Learn MoreUrine-Based DNA Methylation Test Can Detect Bladder Cancer
MONDAY, Aug. 21, 2023 (HealthDay News) — A urine-based DNA methylation test can accurately detect bladder cancer in patients with hematuria, according to a study published online June 14 in The Journal of Molecular Diagnostics.Tae Jeong Oh, from Geno…
Learn MoreExposure to Agent Orange Linked to Risk of Bladder Cancer
WEDNESDAY, June 28, 2023 (HealthDay News) — Exposure to Agent Orange is associated with a small but significantly increased risk of bladder cancer among male Vietnam veterans, according to a study published online June 27 in JAMA Network Open.Steven …
Learn More¿Podría la pérdida del cromosoma Y ayudar a acelerar los cánceres en los hombres?
MIÉRCOLES, 21 de junio de 2023 (HealthDay News) — Todo el mundo sabe que las pérdidas forman parte del envejecimiento masculino: la pérdida del cabello, del tono muscular, de la visión o del oído. Pero, al envejecer, los hombres también comienzan a p…
Learn MoreCould Loss of the Y Chromosome Help Speed Cancers in Men?
WEDNESDAY, June 21, 2023 (HealthDay News) — It’s common knowledge that loss is a part of male aging — loss of hair, loss of muscle tone, loss of vision or hearing.But men growing older also start losing the very thing that makes them biological males…
Learn MoreBladder Cancer Treatment May Lower Risk for Alzheimer and Related Dementias
MONDAY, June 12, 2023 (HealthDay News) — The bacillus Calmette-Guerin (BCG) vaccine is associated with a significantly lower rate and risk for Alzheimer disease and related dementias (ADRD) among patients with bladder cancer, according to a study pub…
Learn MoreASCO: Extended Lymph Node Removal Not Beneficial for Bladder Cancer
THURSDAY, June 8, 2023 (HealthDay News) — For patients with localized muscle-invasive bladder cancer undergoing radical cystectomy, extended lymphadenectomy (LND) is not associated with improved disease-free or overall survival, according to a study …
Learn MorePatients With Bladder Cancer May Avoid Removal of Extra Lymph Nodes, Study Finds
WEDNESDAY, June 7, 2023 (HealthDay News) — For years, doctors have thought that a more extensive surgery that removes a wider swath of lymph nodes was the best option for certain patients with bladder cancer. Now, a new clinical trial is upending tha…
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