SARS-CoV-2 Omicron Infection Linked to Increased Risk for Reinfection

THURSDAY, Aug. 24, 2023 (HealthDay News) -- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) omicron infection is associated with an increased risk for reinfection among residents of long-term care and retirement homes, according to a study published online Aug. 21 in eClinicalMedicine.
Jessica A. Breznik, Ph.D., from McMaster University in Hamilton, Ontario, Canada, and colleagues examined the incidence of SARS-CoV-2 Omicron infection in 750 vaccinated residents of long-term care and retirement homes in an observational study within July to September 2022. In a subset of 318 residents, serum anti-spike and anti-receptor binding domain (RBD) SARS-CoV-2 immunoglobulin (Ig)G and IgA antibodies, microneutralization titers, and spike-specific T-cell memory responses were examined within the preceding three months.
The researchers found that during the observation period, 17.7 percent of the 750 participants had a polymerase chain reaction-confirmed omicron infection. There was an association for increased infection risk with prior omicron infection (at nine to 29 days: 47.67, which was not attributed to days since fourth vaccination or residence outbreaks). After their initial omicron infection, reinfected participants had lower serum neutralizing antibodies to ancestral and omicron BA.1 SARS-CoV-2 and lower anti-RBD IgG and IgA antibodies.
"Overall, our observations caution that immunological features of hybrid immunity are not the same in all older adults, and hybrid immunity should not be considered a panacea against future SARS-CoV-2 infection, whether from cross-subvariant Omicron infections, or future variants of concern," the authors write.
Two authors disclosed ties to the pharmaceutical industry.
Related Posts
Una inyección semanal de insulina podría cambiarlo todo en la diabetes tipo 2
LUNES, 17 de julio de 2023 (HealthDay News) -- Las personas con diabetes tipo 2...
Modifiable Risk Factors Tied to MS Diagnosis, Neurodegeneration
WEDNESDAY, March 9, 2022 (HealthDay News) -- Smoking is associated with higher...
Tooth Abscess: What It Is, Stages, Symptoms & Treatments
MONDAY, April 24, 2023 (HealthDay News) -- If you’ve ever experienced a...
Incidence of Advanced Lung Cancer Continues to Decline in the U.S.
THURSDAY, Jan. 13, 2022 (HealthDay News) -- Continued progress is seen in...