SARS-CoV-2 Omicron Infection Linked to Increased Risk for Reinfection

THURSDAY, Aug. 24, 2023 (HealthDay News) -- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) omicron infection is associated with an increased risk for reinfection among residents of long-term care and retirement homes, according to a study published online Aug. 21 in eClinicalMedicine.
Jessica A. Breznik, Ph.D., from McMaster University in Hamilton, Ontario, Canada, and colleagues examined the incidence of SARS-CoV-2 Omicron infection in 750 vaccinated residents of long-term care and retirement homes in an observational study within July to September 2022. In a subset of 318 residents, serum anti-spike and anti-receptor binding domain (RBD) SARS-CoV-2 immunoglobulin (Ig)G and IgA antibodies, microneutralization titers, and spike-specific T-cell memory responses were examined within the preceding three months.
The researchers found that during the observation period, 17.7 percent of the 750 participants had a polymerase chain reaction-confirmed omicron infection. There was an association for increased infection risk with prior omicron infection (at nine to 29 days: 47.67, which was not attributed to days since fourth vaccination or residence outbreaks). After their initial omicron infection, reinfected participants had lower serum neutralizing antibodies to ancestral and omicron BA.1 SARS-CoV-2 and lower anti-RBD IgG and IgA antibodies.
"Overall, our observations caution that immunological features of hybrid immunity are not the same in all older adults, and hybrid immunity should not be considered a panacea against future SARS-CoV-2 infection, whether from cross-subvariant Omicron infections, or future variants of concern," the authors write.
Two authors disclosed ties to the pharmaceutical industry.
Related Posts
Una alta demanda de pruebas de COVID-19 a domicilio podría obstruir el suministro, advierte Abbott
LUNES, 30 de agosto de 2021 (HealthDay News) -- La demanda de las pruebas para...
Cómo remodelar su vivienda para el acceso en silla de ruedas
JUEVES, 30 de marzo de 2023 (HealthDay News) -- Millones de estadounidenses se...
Beber alcohol en solitario en la juventud es una mala señal de problemas futuros
MARTES, 12 de julio de 2022 (HealthDay News) -- Beber solo quizá tenga...
Muy pocas ciudades de EE. UU. cuentan con buenos planes de evacuación en caso de huracán
VIERNES, 26 de agosto de 2022 (HealthDay News) -- La temporada de huracanes de...