Real-World Data Links Rosuvastatin to Adverse Effects on Kidneys
THURSDAY, Aug. 18, 2022 (HealthDay News) -- Rosuvastatin is associated with increased risks for hematuria, proteinuria, and kidney failure with replacement therapy (KFRT) compared with atorvastatin use, according to a study published online July 19 in the Journal of the American Society of Nephrology.
Jung-Im Shin, M.D., from the Johns Hopkins Bloomberg School of Public Health in Baltimore, and colleagues used deidentified electronic health record data and analyzed 152,101 new users of rosuvastatin and 795,799 new users of atorvastatin from 2011 to 2019. The inverse probability of treatment-weighted hazard ratios of hematuria, proteinuria, and KFRT associated with rosuvastatin were estimated. The dose effect of rosuvastatin was examined on hematuria and proteinuria.
During a median follow-up of 3.1 years, the researchers identified hematuria in 2.9 percent and proteinuria in 1.0 percent of patients. Rosuvastatin use was associated with increased risks for hematuria, proteinuria, and KFRT compared with atorvastatin (hazard ratios, 1.08, 1.17, and 1.15, respectively). Forty-four percent of patients with estimated glomerular filtration rate <30 mL/min/1.73 m2 were prescribed high-dose rosuvastatin (20 or 40 mg daily) even though current labeling suggests dosage reduction (maximum daily dose, 10 mg) for patients with severe chronic kidney disease. With a higher rosuvastatin dose, the risks for hematuria and proteinuria were higher.
"Because rosuvastatin may cause proteinuria and hematuria, especially with high dose, high-dose rosuvastatin may not merit the risk -- even if small -- particularly for patients with advanced kidney disease," Shin said in a statement.
Several authors disclosed financial ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Related Posts
La psilocibina, la droga de los ‘hongos mágicos’, muestra un potencial temprano para aliviar las migrañas
LUNES, 14 de agosto de 2023 (HealthDay News) -- Se renueva el interés en la...
Encuentran pistas de que unos medicamentos similares a la Viagra podrían ayudar a prevenir la demencia
LUNES, 14 de febrero de 2022 (HealthDay News) -- Unos medicamentos similares a...
5-ASA Discontinuation Common Within First Year of Ulcerative Colitis Diagnosis in Youth
WEDNESDAY, Sept. 20, 2023 (HealthDay News) -- For adolescents and young adults...
Parks, Gardens Might Boost Life Spans in Poorer Neighborhoods
WEDNESDAY, Oct. 19, 2022 (HealthDay News) -- The key to narrowing the gap in how...