Rare Coding Variants May Influence Cognition in Schizophrenia

FRIDAY, Oct. 21, 2022 (HealthDay News) -- Ultrarare constrained variants (URCVs) may contribute to variance in cognition in patients with schizophrenia, according to a study published online Aug. 17 in JAMA Psychiatry.
Hugo D.J. Creeth, Ph.D., from Cardiff University School of Medicine in the United Kingdom, and colleagues conducted a within-case genetic association study to examine whether the incidence of rare coding variants is associated with cognition among 802 patients with schizophrenia. Exome sequencing data were assessed for current cognition and for estimated premorbid IQ.
The researchers found an association between URCVs and lower current cognition scores (β = −0.18; P = 0.005). Premorbid IQ was associated with URCVs in a univariable analysis (β = −0.12; P = 0.02) and partially attenuated the association with current cognition (β = −0.09; P = 0.08). In a multivariable analysis, measured genetic factors combined accounted for 6.2 and 10.3 percent of the variance in current cognition and premorbid IQ, respectively, and supported outcomes of URCVs associated with current cognition, irrespective of premorbid IQ (β = −0.10; P = 0.03).
"URCVs were associated with cognitive impairment in schizophrenia, and we found evidence they may independently exert effects after onset of the disorder as well as premorbidly. In our study, the estimated effect sizes were small, but future studies may find that the effect sizes will be greater with better annotation of pathogenic variants," the authors write.
Several authors disclosed ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Related Posts
Parques y áreas de juegos construidos sobre antiguos vertederos podrían tener plomo
LUNES, 18 de septiembre de 2023 (HealthDay News) -- Ese hermoso parque por el...
Pandemic’s Two-Year Global Death Toll May Be Close to 15 Million
WEDNESDAY, Dec. 14, 2022 (HealthDay News) -- Almost 15 million people likely...
Un nuevo fármaco reduce a la mitad las muertes entre los que tienen una COVID grave, afirma el fabricante
MARTES, 12 de abril de 2022 (HealthDay News) -- Un medicamento experimental para...
Autism Symptom Dimension Questionnaire Reliable for Identifying Symptoms
THURSDAY, Jan. 12, 2023 (HealthDay News) -- A revised 39-item version of the...