Open-Label Placebo Studied in Children With Abdominal Pain, IBS

FRIDAY, Feb. 11, 2022 (HealthDay News) -- Open-label placebo (OLP) may have a beneficial effect for the treatment of functional abdominal pain or irritable bowel syndrome in children and adolescents, according to a study published online Jan. 31 in JAMA Pediatrics.
Samuel Nurko, M.D., M.P.H., from Boston Children's Hospital, and colleagues conducted a multicenter crossover randomized clinical trial from July 1, 2015, to June 15, 2018, involving children and adolescents aged 8 to 18 years with functional abdominal pain or irritable bowel syndrome. Participants completed one week of observation and were randomly assigned to OLP for three weeks followed by a three-week control period or a three-week control period followed by three weeks of OLP. Participants took 1.5 mL of an inert liquid placebo twice a day during the OLP period. Participants also were given a bottle of hyoscyamine pills to use as a rescue medication. Data were included for 30 patients: 16 and 14 with functional abdominal pain and irritable bowel syndrome, respectively.
The researchers found that compared with the control period, the mean pain scores were significantly lower during OLP treatment (39.9 versus 45.0; difference, 5.2). Compared with the OLP period, during the control period, patients took nearly twice as many hyoscyamine pills (mean number, 3.8 versus 2.0; difference, 1.8 pills).
"Our findings suggest that OLP may provide an ethical way to harness the placebo effect as a therapeutic tool in the clinic," the authors write. "More research is required to confirm and extend these findings."
Several authors disclosed financial ties to the pharmaceutical and medical device industries.
Abstract/Full Text (subscription or payment may be required)
Related Posts
Las máscaras N-95 son indispensables para la ómicron, pero hay muchas falsificaciones
JUEVES, 30 de diciembre de 2021 (HealthDay News) -- Mientras ve cómo la variante...
Household Air Pollution Linked to Cardiac Autonomic Function in COPD
TUESDAY, Dec. 13, 2022 (HealthDay News) -- For patients with chronic obstructive...
Kids’ Dental Health: Quiz
1. You should start brushing your child's teeth as soon as the first one...
Infant Head-Shaping Pillows Are Useless and Dangerous to Baby, FDA Warns
FRIDAY, Nov. 4, 2022 (HealthDay News) -- Infant head-shaping pillows are not...