Novel Potassium Channel Opener Safe, Effective for Adults With Focal Epilepsy
WEDNESDAY, Oct. 11, 2023 (HealthDay News) -- XEN1101 appears safe and effective for the treatment of focal-onset seizures (FOSs), according to results of a phase 2b study published online Oct. 9 in JAMA Neurology.
Jacqueline A. French, M.D., from the New York University Comprehensive Epilepsy Center in New York City, and colleagues evaluated the efficacy and safety of XEN1101, a novel small-molecule selective Kv7.2/Kv7.3 potassium channel opener, for the treatment of FOS. The analysis included 285 patients who were randomly assigned (2:1:1:2) to receive XEN1101 25, 20, or 10 mg, or placebo with food once daily for eight weeks.
The researchers reported that treatment with XEN1101 was associated with seizure reduction in a robust dose-response manner. From baseline, the median percent reduction in monthly FOS frequency was 52.8 percent for 25 mg, 46.4 percent for 20 mg, and 33.2 percent for 10 mg. Treatment-emergent adverse events were similar to those of commonly prescribed antiseizure medications.
"The results of this study support the further clinical development of XEN1101 for the treatment of FOSs," the authors write. "The findings of this study suggest that XEN1101 has the potential to address the unmet need for a treatment with a novel mechanism of action for patients."
Several authors disclosed ties to pharmaceutical companies, including Xenon Pharmaceuticals, which is developing XEN1101.
Related Posts
Wegovy Lowered Users’ Heart Risks in New Trial
TUESDAY, Aug. 8, 2023 (HealthDay News) -- A large clinical trial weighing the...
Seizures in Young Stroke Survivors Double Dementia Risk
FRIDAY, July 29, 2022 (HealthDay News) -- The onset of seizures in young...
AHA News: Teens’ Research Highlights Lasting Heart Health Effects of Redlining
WEDNESDAY, Nov. 9, 2022 (American Heart Association News) -- Science is about...
El riesgo de EM de los afroamericanos quizá sea más alto de lo que se pensaba
MIÉRCOLES, 14 de junio de 2023 (HealthDay News) -- Durante años, la esclerosis...