Model Developed for Predicting Disease Progression in Hep B Liver Cirrhosis

THURSDAY, April 6, 2023 (HealthDay News) -- For patients with hepatitis B virus (HBV) liver cirrhosis-acute decompensation (LC-AD), a model combining computed tomography (CT) quantified extracellular liver volume (ECVIC-liver) and chronic liver failure consortium-acute decompensation score (CLIF-C ADs) can predict the occurrence of acute-on-chronic liver failure (ACLF), according to a study published online March 29 in Insights into Imaging.
Yang Xu, from Lanzhou University Second Hospital in China, and colleagues conducted a retrospective study to develop and validate a model for predicting the occurrence of ACLF within 90 days in patients with HBV LC-AD. Participants underwent dual-energy CT scans of the liver and were randomly assigned to a training group and a validation group (215 and 92 patients, respectively). The need for readmission within 90 days due to ACLF was the primary outcome.
The researchers found that CLIF-C ADs and ECVIC-liver were independent risk factors for ACLF. In the training and validation groups, the area under the receiver operating characteristic curves of the model combining CLIF-C ADs and ECVIC-liver were 0.893 and 0.838, respectively. Good agreement was seen between predicted and actual risks in calibration curves. The model had good clinical application in a decision curve analysis.
"The results of this study can be used to assist the clinic to better identify the early disease progression in LC-AD patients," the authors write.
Related Posts
Una mujer vacunada del todo se infecta con la ómicron apenas 21 días tras una infección con la delta
JUEVES, 21 de abril de 2022 (HealthDay News) -- Una trabajadora de la atención...
La COVID puede afectar los cerebros de los niños hospitalizados
LUNES, 24 de enero de 2022 (HealthDay News) -- El coronavirus puede dejar a más...
AUA: Outcomes of Robotic, Open Cystectomy Compared in Bladder Cancer
TUESDAY, May 17, 2022 (HealthDay News) -- For patients with nonmetastatic...
La raza y los ingresos afectan su riesgo de sufrir una alergia a un alimento
VIERNES, 16 de junio de 2023 (HealthDay News) -- Aunque, históricamente, las...