Meta-Analysis Shows Prevalence of Statin Intolerance Is Low
WEDNESDAY, Feb. 16, 2022 (HealthDay News) -- The prevalence of statin intolerance (SI) is low, according to a meta-analysis published online Feb. 15 in the European Heart Journal.
Ibadete Bytyçi, from Umeå University in Sweden, and colleagues conducted a meta-analysis to estimate the overall prevalence of SI and factors that might increase the risk for SI. Data were included from 176 studies (112 randomized controlled trials [RCTs] and 64 cohort studies) with 4,143,517 patients.
The researchers found that the prevalence of SI was 9.1 percent overall and was similar when defined using the National Lipid Association, International Lipid Expert Panel, and European Atherosclerosis Society diagnostic criteria (7.0, 6.7, and 5.9 percent, respectively). The prevalence of SI was significantly lower in RCTs versus cohort studies (4.9 versus 17 percent). In studies including both primary and secondary prevention patients, the prevalence of SI was much higher than with a separate analysis of primary or secondary prevention patients (18 percent versus 8.2 and 9.1 percent, respectively). The prevalence of SI was not affected by statin lipid solubility. In the meta-regression model, significant associations with SI were seen for age, female gender, Asian and Black race, obesity, diabetes mellitus, hypothyroidism, chronic liver, and renal failure. An increased risk for SI was also seen in association with antiarrhythmic agents, calcium channel blockers, alcohol use, and increased statin dose.
These results "show that in most cases statin intolerance is over-estimated and over-diagnosed, and they mean that around 93 percent of patients on statin therapy can be treated effectively, with very good tolerability and without any safety issues," a coauthor said in a statement.
Several authors disclosed financial ties to the biopharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Related Posts
Una buena atención de final de vida está fuera del alcance de muchos residentes negros de hogares de ancianos
MARTES, 8 de marzo de 2022 (HealthDay News) -- La atención paliativa puede ser...
¿Qué son los trastornos de la alimentación, y cuáles son las señales?
LUNES, 13 de marzo de 2023 (HealthDay News) -- Los trastornos de la alimentación...
The 3 Midlife Factors That Raise Your Odds for Alzheimer’s
TUESDAY, May 10, 2022 (HealthDay News) -- Certain lifestyle factors can sway the...
C-Section Linked to Increased Risk for Crohn Disease in Offspring
WEDNESDAY, Aug. 24, 2022 (HealthDay News) -- Cesarean delivery is associated...