H. Pylori Infection Negatively Modifies Genetically Increased Risk for Gastric Cancer

THURSDAY, March 30, 2023 (HealthDay News) -- Helicobacter pylori (H. pylori) infection modifies the increased risk for gastric cancer associated with germline pathogenic variants in cancer-predisposing genes, according to a study published in the March 30 issue of the New England Journal of Medicine.
Yoshiaki Usui, M.D., Ph.D., from the RIKEN Center for Integrative Medical Sciences in Yokohama, Japan, and colleagues examined the association between germline pathogenic variants in 27 cancer-predisposing genes and the risk for gastric cancer among 10,426 patients with gastric cancer and 38,153 controls. In addition, the combined effect of pathogenic variants and H. pylori infection status on the risk for gastric cancer was examined; cumulative risk was calculated in 1,433 patients with gastric cancer and 5,997 controls from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC).
The researchers found that germline pathogenic variants in nine genes were associated with gastric cancer risk. With respect to the risk for gastric cancer in HERPACC, there was an interaction observed between H. pylori infection and pathogenic variants in homologous-recombination genes (relative excess risk due to the interaction, 16.01). Compared with noncarriers infected with H. pylori, individuals with H. pylori infection and a pathogenic variant had a higher cumulative risk for gastric cancer at age 85 years (45.5 versus 14.4 percent).
"Our results suggest that in persons known to carry a pathogenic variant in a homologous-recombination gene, evaluation and eradication of H. pylori infection may be particularly important," the authors write.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Related Posts
Prototype Digital Therapeutic Shows Promise for Tinnitus
FRIDAY, Aug. 19, 2022 (HealthDay News) -- For patients with tinnitus, a...
Stronger Breast Implant Safety Measures Announced by FDA
THURSDAY, Oct. 28, 2021 (HealthDay News) -- A boxed warning and a checklist of...
Progress Against Stillbirths Has Stalled in U.S.
TUESDAY, Nov. 15, 2022 (HealthDay News) -- U.S. stillbirth rates still need to...
Digital Tool Accurate for Tracking Movement During Stroke Rehab
TUESDAY, June 21, 2022 (HealthDay News) -- A digital tool is effective for...