FTD-TPI Plus Bevacizumab Increases Survival in Refractory Advanced CRC
THURSDAY, May 4, 2023 (HealthDay News) -- Treatment with trifluridine-tipiracil (FTD-TPI) plus bevacizumab yields longer overall survival than FTD-TPI alone among patients with refractory metastatic colorectal cancer, according to a study published in the May 4 issue of the New England Journal of Medicine.
Gerald W. Prager, M.D., from the Medical University of Vienna, and colleagues randomly assigned adult patients who had received no more than two previous chemotherapy regimens for treatment of advanced colorectal cancer to receive FTD-TPI plus bevacizumab (combination group) or FTD-TPI alone (246 patients assigned to each group).
The researchers found that the median overall survival was 10.8 and 7.5 months in the combination and FTD-TPI groups, respectively (hazard ratio for death, 0.61). Median progression-free survival was 5.6 and 2.4 months in the combination group and FTD-TPI alone group, respectively (hazard ratio for disease progression or death, 0.44). In both groups, the most common adverse events were neutropenia, nausea, and anemia. There were no reports of treatment-related deaths. The median time to worsening of the Eastern Cooperative Oncology Group performance-status score from 0 or 1 to 2 or greater was 9.3 and 6.3 months in the combination and the FTD-TPI groups, respectively (hazard ratio, 0.54).
"The data from this trial confirm that FTD-TPI plus bevacizumab is an effective treatment option for patients with refractory metastatic colorectal cancer, irrespective of mutational status, which side the tumor is on, and whether patients have previously been treated with bevacizumab," the authors write.
The study was funded by Servier and Taiho Oncology.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Related Posts
Mental Health of America’s Children Only Getting Worse
MONDAY, March 14, 2022 (HealthDay News) -- A fresh review of recent government...
ENDO: Disparities Seen in Access to Insulin Pumps for Youth With T1D
WEDNESDAY, June 15, 2022 (HealthDay News) -- There are disparities in access to...
Most Men With Low-Risk Prostate Cancers Now Forgo Immediate Surgery
TUESDAY, April 4, 2023 (HealthDay News) -- Over the last decade, more and more...
Mobile Device May ID Wound Infections Earlier
WEDNESDAY, Aug. 30, 2023 (HealthDay News) -- A mobile device that combines...