Fracture Risk Up With Higher Levels of HDL-C in Healthy Seniors

THURSDAY, Jan. 19, 2023 (HealthDay News) -- For older adults, higher levels of high-density lipoprotein cholesterol (HDL-C) are associated with increased fracture risk, according to a study published online Jan. 18 in JAMA Cardiology.
Sultana Monira Hussain, M.B.B.S., Ph.D., from Monash University in Melbourne, Australia, and colleagues examined whether higher HDL-C levels are predictive of increased fracture risk in older adults in a post hoc analysis of data from the Aspirin in Reducing Events in the Elderly (ASPREE) clinical trial and the ASPREE-Fracture substudy.
Overall, 1,659 of the 16,262 participants with a plasma HDL-C measurement at baseline experienced at least one fracture during a median of 4.0 years. The researchers found that each 1 standard deviation increment in HDL-C level was associated with an increased risk for fracture in a fully adjusted model (hazard ratio, 1.14). When analyses were stratified by sex, the results were similar. These associations persisted when the analyses included only minimal trauma fractures; participants not taking osteoporosis medications; participants who were never smokers and did not drink alcohol; participants who walked outside for less than 30 minutes per day and did not participate in moderate/vigorous physical activity; and only statin use. Non-HDL-C levels were not associated with fractures.
"These findings highlight another potential concern with high HDL-C levels and another likely adverse effect of the drugs that substantially increases plasma HDL-C levels," the authors write. "Further research is needed to determine the pathophysiological explanation for these findings."
Two authors disclosed financial ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Related Posts
Nearly 900,000 U.S. Kids Under 12 Have Gotten Their First COVID Shot
WEDNESDAY, Nov. 10, 2021 (HealthDay News) -- About 900,000 U.S. children aged 5...
Las TC para la detección del cáncer del pulmón encuentra más tumores tempranos
VIERNES, 9 de septiembre de 2022 (HealthDay News) -- Las TC para la detección...
In Utero Exposure to Natural Disaster Ups Child Psychopathology
TUESDAY, Sept. 27, 2022 (HealthDay News) -- In utero exposure to a major...
AHA News: Tiny Sprouts Provide Big Nutrition
TUESDAY, June 7, 2022 (American Heart Association News) -- Move over baby...