First-Line Regimens With Endocrine Therapy Show Benefits in Breast Cancer

TUESDAY, Dec. 20, 2022 (HealthDay News) -- First-line regimens with endocrine therapy (ET) may be associated with benefits among patients with human epidermal growth factor receptor 2-positive (ERBB2-positive [formerly HER2-positive]) metastatic breast cancer (MBC), according to a study published online Dec. 15 in JAMA Network Open.
Marcela Carausu, M.D., from Institut Curie in Saint-Cloud, France, and colleagues evaluated the association of hormone receptor status and first-line inclusion of ET with outcomes among patients with ERBB2-positive MBC. The analysis used clinical data from the French clinical Epidemiological Strategy and Medical Economics cohort of 4,145 patients who started treatment between 2008 and 2017 with follow-up through June 18, 2020.
The researchers observed no significant difference in overall or progression-free survival for 1,520 patients treated with ERBB2-targeted therapy with chemotherapy and with or without ET versus 203 patients receiving ERBB2-targeted therapy with ET. Findings were seen regardless of type of ERBB2-targeted therapy (trastuzumab or trastuzumab with pertuzumab). In propensity-matched patients, results were similar. Among patients with ERBB2-targeted therapy with chemotherapy, those with maintenance ET had significantly better progression-free (hazard ratio, 0.70) and overall survival (hazard ratio, 0.47).
"Our findings suggest that ET-containing regimens may be associated with benefits for a subgroup of patients, suggesting that results from randomized clinical trials investigating a more personalized approach for these patients may be relevant and necessary," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
Related Posts
1 in 500 Americans Has Died From COVID-19
WEDNESDAY, Sept. 15, 2021 (HealthDay News) -- One out of every 500 U.S....
2001 to 2020 Saw Shift in Rx for Disease-Modifying Therapy for Multiple Sclerosis
THURSDAY, July 27, 2023 (HealthDay News) -- Oral disease-modifying therapies...
Por qué dejar de fumar puede ser un poco más difícil para las mujeres
LUNES, 17 de enero de 2022 (HealthDay News) -- Dejar de fumar es un reto...
Occurrence of Cardiovascular Events, Death Compared Between Thiazides
TUESDAY, Jan. 3, 2023 (HealthDay News) -- For patients receiving thiazide...