Evidence Found of Causal Link for Multisite Chronic Pain and MS, RA

WEDNESDAY, Feb. 22, 2023 (HealthDay News) -- Multisite chronic pain is causally associated with a higher risk for multiple sclerosis (MS) and rheumatoid arthritis (RA), but not with other autoimmune diseases (AIDs), according to a study published online Feb. 9 in Frontiers in Immunology.
Yidan Tang, from Sichuan University in Chengdu, China, and colleagues used a two-sample Mendelian randomization (MR) method to determine the causal relationship between chronic pain and AIDs, namely amyotrophic lateral sclerosis (ALS), celiac disease (CeD), inflammatory bowel disease (IBD), MS, RA, systemic lupus erythematosus (SLE), type 1 diabetes (T1D), and psoriasis using genome-wide association study summary statistics.
The researchers identified associations between multisite chronic pain and a higher risk for MS and RA (odds ratios, 1.59 and 1.72, respectively) with utilization of an MR analysis. No significant effect was seen for multisite chronic pain on ALS, CeD, IBD, SLE, T1D, or psoriasis. Positive causal effects of multisite chronic pain on body mass index (BMI) were identified, as were causal effects of BMI on MS and RA. Genetically predicted chronic widespread pain was not causally connected to the risk for most types of AIDs.
"Our results demonstrated genetic evidence of a potential causal relationship between multisite chronic pain and MS or RA in the European population, which may partially mediate through BMI," the authors write.
Related Posts
Dejar de fumar podría ayudar a mejorar el suministro de comida de las familias más pobres
JUEVES, 4 de mayo de 2023 (HealthDay News) -- Dejar de fumar podría dejarle más...
ASCO: FOLFOX Noninferior to Chemoradiotherapy for Overall Survival in Rectal Cancer
FRIDAY, June 9, 2023 (HealthDay News) -- Neoadjuvant chemotherapy with...
El impacto del racismo podría ralentizar la recuperación tras un ataque cardiaco
MARTES, 1 de noviembre de 2022 (HealthDay News) -- La discriminación no solo...
Cancer Can Strike the Appendix, Too
TUESDAY, March 22, 2022 (HealthDay News) -- What appears to be appendicitis can...