Effect of Noradrenergic Drugs Explored in Alzheimer Disease
FRIDAY, July 29, 2022 (HealthDay News) -- Noradrenergic drugs seem to have a positive effect for general cognition and apathy in Alzheimer disease, according to a review published online July 5 in the Journal of Neurology, Neurosurgery & Psychiatry.
Michael C.B. David, M.B.B.S., from Imperial College London, and colleagues conducted a systematic review and meta-analysis to examine the efficacy of drugs with principally noradrenergic action in improving cognitive and neuropsychiatric symptoms in Alzheimer disease.
Nineteen randomized controlled trials with 1,811 patients were included; of these trials, six, seven, and six were judged as good, fair, and poor quality, respectively. The researchers found that noradrenergic drugs had a significant, small positive effect on global cognition in a meta-analysis of 10 trials (1,300 patients), measured using the Mini-Mental State Examination or Alzheimer’s Disease Assessment Scale-Cognitive subscale. There was no significant effect on measures of attention. A large positive effect of noradrenergic drugs was detected in the meta-analysis of eight trials (425 patients) examining apathy. After removal of outliers to account for heterogeneity across studies, this positive effect was still present.
"Based on this meta-analysis, and recognition of the importance of locus coeruleus-noradrenergic system in multiple neurodegenerative diseases, there is a case for further clinical trials of noradrenergic agents in Alzheimer's disease and other neurodegenerative conditions," the authors write.
Related Posts
Hearing, Vision Impairment Up Odds of Cognitive Decline in Seniors
TUESDAY, May 10, 2022 (HealthDay News) -- Hearing, vision, and dual sensory...
Risk for Acute MI Not Increased With Two-Dose HepB-CpG Vaccine
FRIDAY, April 1, 2022 (HealthDay News) -- The rate of type 1 acute myocardial...
Muchos pacientes no reciben la cirugía de mejor calidad para el cáncer de pulmón, según un estudio
LUNES, 23 de enero de 2023 (HealthDay News) -- La habilidad de un cirujano tiene...