Early Aggressive Fluid Resuscitation Not Better for Pancreatitis

FRIDAY, Sept. 16, 2022 (HealthDay News) -- Early aggressive fluid resuscitation results in a higher incidence of fluid overload and does not improve clinical outcomes for patients presenting with acute pancreatitis, according to a study published in the Sept. 15 issue of the New England Journal of Medicine.
Enrique de-Madaria, M.D., Ph.D., from Dr. Balmis General University Hospital in Alicante, Spain, and colleagues randomly assigned 249 patients at 18 centers who presented with acute pancreatitis to receive goal-directed aggressive or moderate resuscitation with lactated Ringer's solution. Patients were assessed at 12, 24, 48, and 72 hours; fluid resuscitation was adjusted based on the patient's clinical status.
The trial was halted due to between-group differences in the safety outcomes, with no significant difference in the incidence of moderately severe or severe pancreatitis between the groups (22.1 and 17.3 percent in the aggressive- and moderate-resuscitation groups, respectively; adjusted relative risk, 1.30; 95 percent confidence interval, 0.78 to 2.18; P = 0.32). The researchers found that fluid overload developed in 20.5 and 6.3 percent of those who received aggressive and moderate resuscitation, respectively (adjusted relative risk, 2.85; 95 percent confidence interval, 1.36 to 5.94; P = 0.004). The median duration of hospitalization was six and five days in the aggressive- and moderate-resuscitation groups, respectively.
"The use of aggressive fluid resuscitation led to a higher risk of volume overload and did not show the hypothesized benefit in disease-specific outcomes," the authors write.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Was this page helpful?
Related Posts
¿Quién tiene COVID? Los perros pueden saberlo rápidamente
MIÉRCOLES, 16 de agosto de 2023 (HealthDay News) -- ¿Tiene COVID-19? Con un poco...
Aparecen más casos de viruela del mono en Portugal mientras el brote se amplía
MIÉRCOLES, 18 de mayo de 2022 (HealthDay News) -- Después de que a principios de...
Intensive Inpatient BP Management Not Beneficial in Seniors
WEDNESDAY, June 21, 2023 (HealthDay News) -- For hospitalized older adults with...
Research Needed to Understand Impact of Low-Dose Radiation
FRIDAY, June 10, 2022 (HealthDay News) -- Multidisciplinary research is needed...