Dexamethasone No Benefit in HIV-Positive With Tuberculous Meningitis

THURSDAY, Oct. 12, 2023 (HealthDay News) -- For HIV-positive adults with tuberculous meningitis, adjunctive dexamethasone does not confer a benefit with respect to survival, according to a study published in the Oct. 12 issue of the New England Journal of Medicine.
Joseph Donovan, Ph.D., from the Oxford University Clinical Research Unit in Ho Chi Minh City, Vietnam, and colleagues conducted a double-blind, randomized, placebo-controlled trial involving HIV-positive adults with tuberculous meningitis in Vietnam and Indonesia. In addition to 12 months of antituberculosis chemotherapy, participants were randomly assigned to receive a six- to eight-week tapering course of dexamethasone or placebo (263 and 257, respectively).
The researchers found that during 12 months of follow-up, death occurred in 44.1 and 49.0 percent of participants in the dexamethasone and placebo groups, respectively (hazard ratio, 0.85; 95 percent confidence interval, 0.66 to 1.10; P = 0.22). In prespecified analyses, no subgroup was found that clearly benefited from dexamethasone. The two trial groups had a similar incidence of secondary end points, including cases of immune reconstitution inflammatory syndrome during the first six months. The two groups had similar numbers of participants with at least one serious adverse event (73.0 and 75.5 percent, respectively).
"We did not find a benefit of adjunctive dexamethasone in HIV-positive adults with tuberculous meningitis with respect to survival or any secondary end point over a period of 12 months," the authors write.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Related Posts
Physician’s Briefing Weekly Coronavirus Roundup
Here is what the editors at Physician's Briefing chose as the most important...
Las estatinas reducen los riesgos cardiacos de las personas con VIH
JUEVES, 13 de abril de 2023 (HealthDay News) -- A medida que las personas con...
Ketamine Shows Promise Against Treatment-Resistant Depression in Trial
TUESDAY, July 18, 2023 (HealthDay News) -- Dr. Dan Iosifescu’s patient had a...
El riesgo de COVID por las superficies de los supermercados es muy bajo, según un estudio
MARTES, 12 de octubre de 2021 (HealthDay News) -- Las probabilidades de contraer...