Cystatin C-Based eGFR Strongly Correlates With Creatinine-Based eGFR

MONDAY, March 6, 2023 (HealthDay News) -- Cystatin C estimation of glomerular filtration rate (eGFR) correlates strongly with creatinine eGFR but can have a substantial effect on chronic kidney disease (CKD) staging, according to a study published in the March issue of Kidney Medicine.
Eric Raphael Gottlieb, M.D., from Mount Auburn Hospital in Cambridge, Massachusetts, and colleagues examined how cystatin C correlates with creatinine eGFR and how it indicates differences in CKD staging. The analysis included 1,783 inpatients and outpatients who had cystatin C and creatinine levels drawn within 24 hours.
The researchers found that cystatin C-based eGFR was very strongly correlated with creatinine-based eGFR (Spearman correlation ρ = 0.83). Cystatin C eGFR resulted in no change to CKD stage for two-thirds of patients but resulted in a change to a later CKD stage in 27 percent and an earlier stage in 7 percent. There was a lower likelihood of change to a later stage for Black patients (odds ratio, 0.53), while age (odds ratio per year, 1.03) and Elixhauser score (odds ratio per point, 1.22) were associated with a higher likelihood of change to a later stage.
"This study demonstrates the importance of a broad campaign to educate clinicians and develop guidelines regarding the application of cystatin C eGFR and to mitigate the confusion that differences between creatinine eGFRs may raise," the authors write.
One author disclosed financial ties to the pharmaceutical industry.
Related Posts
U.S. Teens Were Already in Mental Health Crisis Before Pandemic Hit
MONDAY, Jan. 24, 2022 (HealthDay Now) -- Alaina Stanisci has grappled with an...
¿Por qué tan pocos adultos mayores reciben rehabilitación para la insuficiencia cardiaca?
MARTES, 9 de noviembre de 2021 (HealthDay News) -- La insuficiencia cardiaca...
Excess Body Fat Tied to Lower Cognitive Scores in Adults
TUESDAY, Feb. 1, 2022 (HealthDay News) -- Both generalized and visceral...
Fauci tiene un ‘rebote’ de la COVID tras tomar Paxlovid, pero afirma que el fármaco lo salvó del hospital
JUEVES, 30 de junio de 2022 (HealthDay News) -- Después de infectarse con la...