Challenges Persist for Pediatric Clinical Trials

TUESDAY, March 22, 2022 (HealthDay News) -- Early discontinuation and nonreporting/nonpublication of findings continue to be common issues for conducting pediatric clinical trials, according to a study published online March 22 in Pediatrics.
Ryan Brewster, M.D., from the Stanford University School of Medicine in California, and colleagues characterized the prevalence of and factors associated with early discontinuation, results reporting, and publication of clinical trials enrolling participants <18 years of age that were registered at ClinicalTrials.gov from October 2007 to March 2020.
The researchers found that 11.1 percent of the trials were stopped early; the predominant reason for discontinuation was recruitment failure. Results were reported for 23.5 percent of completed trials; 38.8 percent were published within three years of completion. Over the study period, there was a significant improvement observed in rates of discontinuation and publication. The odds of discontinuation were lower for government-sponsored trials and academic trials versus industry trials (adjusted odds ratios, 0.72 and 0.64, respectively), and they were more likely to be published (adjusted odds ratios, 1.94 and 1.61, respectively). The likelihood of reporting results was lowest for academic trial investigators (adjusted odds ratio, 0.34).
"As the pediatric clinical trial ecosystem expands, so too must the mechanisms to address unique ethical, economic, and epidemiological barriers be prioritized," the authors write. "Ultimately, addressing ongoing gaps in pediatric trial completion and availability of research findings will ensure that all children receive the highest quality, evidence-based care."
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Related Posts
GI Troubles Can Persist for Years in Women Who Survive Colon Cancer
MONDAY, Aug. 7, 2023 (HealthDay News) -- Colon cancer survivors are living...
Even Transient Food Allergy in Infancy Impacts Later Lung Function
WEDNESDAY, Aug. 2, 2023 (HealthDay News) -- Food allergy in infancy, whether it...
Kaiser Permanente Reaches Tentative Deal With 75,000 Health Care Workers
FRIDAY, Oct. 13, 2023 (HealthDay News) -- A tentative deal has been reached...
Firearms Now the Leading Cause of Death Among U.S. Kids, Teens
FRIDAY, April 22, 2022 (HealthDay News) -- Guns have surpassed road crashes as...