Ceftobiprole Noninferior to Daptomycin for Complicated Staph Infection

WEDNESDAY, Oct. 4, 2023 (HealthDay News) -- For patients with complicated Staphylococcus aureus bacteremia, ceftobiprole is noninferior to daptomycin for overall treatment success, according to a study published online Sept. 27 in the New England Journal of Medicine.
Thomas L. Holland, M.D., from Duke University in Durham, North Carolina, and colleagues conducted a phase 3 noninferiority trial involving adults with complicated S. aureus bacteremia who were randomly assigned to receive ceftobiprole or daptomycin plus optional aztreonam at the discretion of the investigators (189 and 198 patients, respectively). The primary outcome was overall treatment success 70 days after randomization, with a noninferiority margin of 15 percent.
The researchers found that 69.8 and 68.7 percent of the patients in the ceftobiprole and daptomycin groups, respectively, had overall treatment success (adjusted difference, 2.0 percentage points; 95 percent confidence interval, −7.1 to 11.1). In key subgroups and with respect to secondary outcomes, including mortality and the percentage of patients with microbiologic eradication, the findings were consistent between the groups. Adverse events were reported in 63.4 and 59.1 percent of patients receiving ceftobiprole and daptomycin, respectively; serious adverse events were reported in 18.8 and 22.7 percent.
"In addition, microbiologic eradication, relapse of bacteremia, and new or worsening S. aureus bacteremia complications were similar in the two trial groups, findings that further indicate that ceftobiprole was not less effective than daptomycin," the authors write.
Several authors disclosed ties to biopharmaceutical companies, including Basilea Pharmaceutica International, which markets ceftobiprole and partially funded the study.
Abstract/Full Text (subscription or payment may be required)
Related Posts
¿La raza afecta a las probabilidades de desarrollar EM?
MARTES, 3 de mayo de 2022 (HealthDay News) -- Los estadounidenses negros son más...
Holidays Are Peak Time for Heart Attack: Protect Yourself
SUNDAY, Dec. 12, 2021 (HealthDay News) -- This time of year can be hard on the...
La fibrilación auricular podría aumentar las probabilidades de demencia
LUNES, 13 de marzo de 2023 (HealthDay News) -- El latido cardiaco irregular...
Los CDC relajan las normas sobre la vacunación contra la COVID para los viajeros extranjeros
VIERNES, 28 de abril de 2023 (HealthDay News) -- Los viajeros a Estados Unidos...