Bivalent mRNA-1273.214 Elicits Better Response Against Omicron
TUESDAY, Sept. 27, 2022 (HealthDay News) -- Interim results of an ongoing study show that use of the bivalent omicron-containing vaccine mRNA-1273.214 as a second booster elicits neutralizing antibody responses against omicron that are superior to those for mRNA-1273, according to a study published online Sept. 16 in the New England Journal of Medicine.
Spyros Chalkias, M.D., from Moderna in Cambridge, Massachusetts, and colleagues compared the 50-μg bivalent vaccine mRNA-1273.214 (25 μg each of ancestral Wuhan-Hu-1 and omicron B.1.1.529 [BA.1] spike messenger RNAs) with the previously authorized 50-μg mRNA-1273 booster in an ongoing phase 2 to 3 study. mRNA-1273.214 or mRNA-1273 was administered as a booster to adults who had previously received a two-dose primary series and first booster dose of mRNA-1273 three or more months earlier (437 and 377 participants, respectively).
The researchers found that for participants with no previous severe acute respiratory syndrome coronavirus 2 infection, the geometric mean titers of neutralizing antibodies against the omicron BA.1 variant were 2,372.4 and 1,473.5 after receipt of the mRNA-1273.214 and mRNA-1273 boosters, respectively. In addition, the mRNA-1273.214 and mRNA-1273 boosters elicited geometric mean titers of 727.4 and 492.1, respectively, against omicron BA.4 and BA.5; higher binding antibody responses against multiple other variants was elicited by the mRNA-1273.214 booster versus the mRNA-1273 booster. The two boosters had similar safety and reactogenicity.
"These results are consistent with the evaluation of our bivalent beta-containing vaccine, which induced enhanced and durable antibody responses," the authors write. "Together, these findings indicate that bivalent vaccines may be a new tool in the response to emerging variants."
Several authors disclosed financial ties to pharmaceutical companies, including Moderna, which funded the study.
Related Posts
Experts Push Back Against Rush for COVID Booster Shots
FRIDAY, Sept. 3, 2021 (HealthDay News) -- Opposition is mounting among U.S. and...
Pandemic May Have Left Lessons on C-Section ‘Preemie’ Births
TUESDAY, April 12, 2022 (HealthDay News) -- There was a 6.5% drop in premature...
Physical Activity Monitors With Feedback Effective in Adults
MONDAY, Jan. 31, 2022 (HealthDay News) -- Physical activity monitor (PAM)-based...
Advierten a los viajeros de EE. UU. sobre pastillas falsas con fentanilo en farmacias de México
LUNES, 20 de marzo de 2023 (HealthDay News) -- ¿Piensa viajar a México? Tenga...