Bilateral Oophorectomy May Up Risk for Developing Dementia
WEDNESDAY, Feb. 9, 2022 (HealthDay News) -- Bilateral, but not unilateral, oophorectomy is associated with an increased rate of subsequent dementia, according to a study published online Jan. 31 in Menopause.
Cecilie S. Uldbjerg, from the University of Copenhagen in Denmark, and colleagues used data from 24,851 female participants in the Danish Nurse Cohort to examine the association between oophorectomy and incident dementia.
The researchers observed a higher rate of dementia following bilateral oophorectomy (adjusted rate ratio, 1.18; 95 percent confidence interval, 0.89 to 1.56) and a lower rate following unilateral oophorectomy (adjusted rate ratio, 0.87; 95 percent confidence interval, 0.59 to 1.23) compared with nurses who retained their ovaries. When stratifying by age at oophorectomy, similar results were seen. Hysterectomy or hormone therapy did not significantly modify the effects.
"These results are consistent with findings of prior studies showing a link between oophorectomy and dementia. The statistical power of the study was limited, which may explain the lack of effect of age or hormone therapy use on this association," Stephanie Faubion, M.D., medical director of the North American Menopause Society, said in a statement. "Given the robust body of evidence suggesting potential long-term adverse effects associated with oophorectomy before the average age of menopause, risk-reducing oophorectomy should be limited to those women with an inherited high risk for cancer."
Abstract/Full Text (subscription or payment may be required)
Related Posts
Rate of Positive Laparoscopy High for Patients With Pancreatic Cancer
TUESDAY, Aug. 15, 2023 (HealthDay News) -- For patients with pancreatic ductal...
Do Older Patients Need Radiation Rx After Breast Cancer Surgery?
THURSDAY, Feb. 16, 2023 (HealthDay News) -- Many older women with early-stage...
Model Predicts Impact of Food Choices on Life Expectancy
WEDNESDAY, Feb. 16, 2022 (HealthDay News) -- Young adults who are willing to...
Eosinophilic Cellulitis Seems to Be Type 2 Inflammatory Disease
WEDNESDAY, June 21, 2023 (HealthDay News) -- Eosinophilic cellulitis seems to be...